Differential down-regulation of protein kinase C subspecies in KM3 cells
نویسندگان
چکیده
منابع مشابه
Down regulation of protein kinase C in neuronal cells: effects on neurotransmitter release.
We investigated the effects of phorbol esters on protein kinase C (PKC) activity and on neurotransmitter release from cultured neuronal cells. Both differentiated and undifferentiated PC12 pheochromocytoma cells contained high levels of protein PKC. Under normal conditions all the enzyme activity was found in the cytoplasm. Addition of the phorbol esters phorbol 12-myristate-13-acetate (TPA) or...
متن کاملDifferential localization of four subspecies of protein kinase C in the rat striatum and substantia nigra.
The distribution of protein kinase C (PKC) subspecies and their colocalization with neurotransmitters were examined in the rat striatum and substantia nigra (SN), using immunocytochemistry. The alpha- and beta I-PKC immunoreactivies were seen predominantly in the perikarya of the neurons in the striatum and SN. In contrast, the beta II- and gamma-PKC immunoreactivities were abundant in both the...
متن کاملMolecular heterogeneity and differential expression of multiple protein kinase C subspecies in central nervous tissue.
encoding N-CAM-140 (Murray et al., 1986). The nature of the remaining extracellular coding region of the human muscle transmembrane protein isoform awaits further characterization of cDNA clones. The restriction maps of these further clones have some similarity with the 5' EcoRl fragment of 11, but from restriction mapping there appears to be some sequence heterogeneity at the 5' ends of the cD...
متن کاملDifferential regulation of protein kinase C isozymes by thyrotropin-releasing hormone in GH4C1 cells.
GH4C1 cells, which express Ca(2+)-dependent alpha- and beta- as well as Ca(2+)-independent gamma-, epsilon- and zeta-protein kinase C (PKC) isozymes, provide a cell culture model for studying isozyme-specific properties and functions. Hormonal activation of PKCs regulates the differentiated functions of these cells, namely secretion and synthesis of prolactin (PRL). We previously reported that ...
متن کاملDifferential Regulation of Cysteinyl Leukotriene Receptor Signaling by Protein Kinase C in Human Mast Cells
Cysteinyl leukotrienes (cys-LTs) are a group of lipid mediators that are potent bronchoconstrictors, powerful inducers of vascular leakage and potentiators of airway hyperresponsiveness. Cys-LTs play an essential role in asthma and are synthesized as well as activated in mast cells (MCs). Cys-LTs relay their effects mainly through two known GPCRs, CysLT1R and CysLT2R. Although protein kinase C ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Letters
سال: 1988
ISSN: 0014-5793
DOI: 10.1016/0014-5793(88)80064-4